![]() This work involves building centromeric chromatin from its component parts for analysis of its physical characteristics, developing biochemical assays to reconstitute steps in the process of establishing and maintaining the epigenetic mark, exploiting emerging genomic and epigenomic technologies to investigate the structure of centromeric chromatin, and using cell and organismal approaches to study the behavior of proteins involved in centromere inheritance and other essential aspects related to chromosome segregation at cell division. By taking biophysical, biochemical, genetic, epigenomic, and cell biological approaches, our work is to define the composition and physical characteristics of the protein and protein/DNA complexes that epigenetically mark the location of the centromere on the chromosome. These centromeric proteins interact directly with the DNA to create a specialized chromatin compartment that is distinct from any other part of the chromosome. Rather, the location of the centromere is dictated by an epigenetic mark generated by one or more resident proteins. In humans, the chromosomal element-the centromere-that directs this process is not defined by a particular DNA sequence. The longest standing goal of my lab has been to understand how particular proteins direct accurate chromosome segregation at mitosis and meiosis. Skip Brass, MD, PhD, Associate Dean and Director of the Penn MSTP ( Interests: Faculty updates should be sent to Hope Charney ( Penn faculty who are not currently listed but would like to be should contact Skip Brass and check out the MSTP or VMD/PhD website for more information about the program, the students who are in it, and the careers of our alumni. Current students should use this directory in combination with other sources of information and advice, especially from their graduate programs. Others would very much like to, but not every Penn faculty member who would make a splendid thesis mentor is currently included. ![]() Many of the faculty included in the directory either have or have had MD/PhD and VMD/PhD students as part of their research teams. The directory is also here to help applicants to the MSTP learn more about Penn and the faculty who work here. The directory exists to assist recently-arrived students identify potential mentors for research rotations and thesis projects. MSTP trainers directory Welcome to the Penn MSTP Faculty Trainer DirectoryĮach of the Penn faculty members included in this directory has made an explicit commitment to good mentorship practices in the training of future physician-scientists in Penn’s MD/PhD and VMD/PhD programs. ![]()
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